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KMID : 0895820040140010035
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Journal of Oriental Rehabilitation Medicine
2004 Volume.14 No. 1 p.35 ~ p.52
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The E ffec t o f Intra-articu la r B ee V enom Injection on O steo a rth ritis o f th e K n ee
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Ryu Su-Min
Chung Seok-Hee
Kim Sung-Su
Lee Jong-Soo
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Abstract
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Objective: Bee venom has traditionally been used in Oriental medicine to relieve inflammatory pain related to arthritis. While several investigators have evaluated the effect of bee venom treatment by subcutaneous injection technique, the effect of bee venom treatment by intra-articular injection technique has not been examined. In this study, we tried to examine the therapeutic effect of intra-articular bee venom injection on osteoarthritis of knee joint.
Methods: 51 outpatients with osteoarthritis visiting Dept. of oriental rehabilitation medicine were randomized into two groups : 26 samples and 25 controls. Control group took traditional needle acupuncture therapies, 3 times a week for 4 weeks, while sample group(B-V group) took the same treatments and intra-articular bee venom injection therapies in addition. Outcomes were measured by 100mm VAS(Visual Analogue Scale), WOMAC(Western Ontario and McMaster Universities Osteoarthritis Index), and Lequesne’s index at baseline and every week until 4 weeks.
Results: 1. B-V group showed significantly greater improvement at 1 week in VAS score.
2. B-V group showed significantly greater improvement at 2 weeks in WOMAC total score.
3. B-V group showed significantly greater improvement in WOMAC pain and disability score after treatments.
4. WOMAC stiffness scores were not significantly different between B-V and control group after treatments.
5. B-V group showed significantly greater improvement in Lequesne’s index at 3 weeks.
Conclusions: In this clinical study, intra-articular bee venom injection therapy was more effective in improving pain, disability of knee joint caused by osteoarthritis than traditional needle acupuncture therapy alone.
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KEYWORD
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Bee Venom, Intra-articular Injection, Knee, Osteoarthritis, Acupuncture
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